Carcinoembryonic antigen radioimmunodetection
نویسندگان
چکیده
منابع مشابه
Radioimmunodetection of gastrointestinal neoplasms with antibodies to carcinoembryonic antigen.
Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction imaging. In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successf...
متن کاملRadioimmunodetection of primary and metastatic ovarian cancer using radiolabeled antibodies to carcinoembryonic antigen.
131I-labeled goat immunoglobulin G (IgG) prepared against carcinoembryonic antigen (CEA) was administered at an average dose of 1.0 mCi (180 to 250 microgram IgG protein) to patients with ovarian tumors in order to evaluate this method of tumor detection and localization, termed the radioimmunodetection of cancer. All primary cancers in 13 patients could be localized, whereas the metastases in...
متن کاملImmunological considerations in the use of goat antibodies to carcinoembryonic antigen for the radioimmunodetection of cancer.
Preparation of radioantibodies from carcinoembryonic antigen (CEA) antisera raised in goats by conventional procedures necessitates extensive absorption procedures to remove antibody activity against CEA-related substances. Further purification by affinity chromatography increases the antibody content of the radiolabeled preparation and enhances antibody uptake by a xenogeneic tumor. In patient...
متن کاملImmunological Considerations in the Use of Goat Antibodies to Carcinoembryonic Antigen for the Radioimmunodetection of Cancer1
Preparation of radioantibodies from carcinoembryonic anti gen (CEA) antisera raised in goats by conventional procedures necessitates extensive absorption procedures to remove anti body activity against CEA-related substances. Further purifi cation by affinity chromatography increases the antibody con tent of the radiolabeled preparation and enhances antibody uptake by a xenogeneic tumor. In pat...
متن کاملClinical studies of cancer radioimmunodetection with carcinoembryonic antigen monoclonal antibody fragments labeled with 123I or 99mTc.
Seventy-three patients with diverse cancers containing carcinoembryonic antigen received 123I-labeled anti-carcinoembryonic antigen monoclonal antibody F(ab')2 fragment [38 patients], 99mTc-labeled anti-carcinoembryonic antigen monoclonal antibody Fab' fragment [23 patients], or both reagents at different times [6 patients] for evaluation of antibody targeting and imaging [radioimmunodetection ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1983
ISSN: 0016-5085
DOI: 10.1016/0016-5085(83)90096-3